Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
نویسندگان
چکیده
منابع مشابه
Role of Nuclear Receptors Steroidogenic Factor-1, DAX-1, and Estrogen Receptor
Steroid hormone biosynthesis by the fetal adrenal gland is crucial to the integrity and continuation of pregnancy, growth of the fetal and maternal tissues, as well as perinatal homeostatic adaptation for extrauterine survival. The adrenal cortex in the primate undergoes a remarkable morphological and functional remodeling such that the fetal adrenal cortex transforms into an adult adrenal cort...
متن کاملThe structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in t...
متن کاملThe nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.
Classical ligand-activated nuclear receptors (e.g. thyroid hormone receptor, retinoic acid receptor), orphan nuclear receptors (e.g. Rev-erbAalpha/beta), Mad/Max bHLH (basic helix loop helix)-LZ proteins, and oncoproteins, PLZF and LAZ3/BCL6, bind DNA and silence transcription by recruiting a repressor complex that contains N-CoR (nuclear receptor corepressor)/SMRT (silencing mediator of retino...
متن کاملAdrenal Organogenesis and 2 Steroidogenesis Role of Nuclear Receptors Steroidogenic Factor-1, DAX-1, and Estrogen Receptor
Steroid hormone biosynthesis by the fetal adrenal gland is crucial to the integrity and continuation of pregnancy, growth of the fetal and maternal tissues, as well as perinatal homeostatic adaptation for extrauterine survival. The adrenal cortex in the primate undergoes a remarkable morphological and functional remodeling such that the fetal adrenal cortex transforms into an adult adrenal cort...
متن کاملOrphan Nuclear Receptor DAX-1 acts as a novel corepressor of LXR and inhibits hepatic lipogenesis
1 Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea; 2 Research Institute of Medical Sciences, Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501746, Republic of Korea; 3 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Repub...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.5.2949